Asian Journal of Pharmaceutical Research

Abstract

The word or term “Nutraceutical” is a combination of two words i.e. “Nutrition” and “Pharmaceutical”. The term 'nutraceutical' was coined in 1989 by DeFelice. Basically nutraceutical is a food or part of food and it has huge historical background regarding to treatment of various disease. Nutraceuticals plays a significant role in normal physiological function, which helps to maintain human health. In recent period, all people are conscious about their daily diet as well as health. In India many people have preconception or prejudice about nutrition and health. India is a developing country. So many people of rural areas are suffering from non-communicable diseases and disorders due to lack of proper knowledge about nutrition, food and diet. The present article provides some information about “Nutraceuticals and human health. In recent years there is a growing interest in nutraceuticals has been seen in market place. This article mainly helps to provide essential knowledge of nutraceutical with its numerous uses in various ailments. This article also contains important legal requirements that are necessary for register a nutraceutical product.

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Abstract

Introduction: Psoriasis (Ps) is a well-known chronic non-infectious, inflammatory skin disease affecting about 2–3% of the worldwide Population. Pathogenesis includes the environmental trigger factors with other factors like genetic factors, trauma, chemicals, bacterial infection etc. Currently there is no drug which can permanently cure the skin lesions as well as completely eradicate this dermatosis. The purpose of this research is to investigate the anti-psoriatic activity of phytoconstituents of Tribulus terrestris by predicting the ligand-receptor binding and by predicting the ADMET parameters using Lipinski's rule. Methodology: The process of research work starts with protein and ligand structure preparation. Further docking was done using PyRxAutodock Vina. Afterward, analysis and visualisation of the interaction between protein-ligands was done, and ADMET profiling was carried out according to lipinski's rules using Swiss ADME. Result: we selected four phytoconstituents of Tribulus terrestris. Molecular docking simulation showed all four compounds had better binding affinities. Based on the results of prediction of ADMET values using the Lipinski rule, compound that are thought to have good activity. Conclusion: Based on results these molecules have discovered that they may be able to produce anti-psoriatic activity and found that they have a lower toxicity, and ADME analysis determined the easily absorbability to the tissue site. Hence, these compounds can be analysed by further in vitro studies and can be a leader in the designing of the potential drug for the psoriasis management.

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